Phytochemical Profile, Antioxidant Activity and Cholinesterase Inhibition Potential of Essential Oil and Extracts of Teucrium montanum from Bosnia and Herzegovina

Bioactive compounds from plants play an important role in slowing many neurodegenerative diseases, such as Alzheimer’s disease, by inhibiting cholinesterase enzymes. Studies have shown that oxidative stress is associated with the development of disease. In traditional medicine Bosnia and Herzegovina, Teucrium montanum used to treat numerous diseases. The chemical composition biological activity essential oil (EO) aqueous (AE) methanol extract (ME) this plant were studied. EO was studied using GC-MS, while extracts HPLC-DAD. Antioxidant tested DPPH FRAP methods. protection lipids proteins oxidation ammonium thiocyanate BSA ability inhibit cholinesterases Ellman method. main identified α-cadinol, ß-selinene, δ-cadinene, epi-α-cadinol, germacrene D-4-ol, α-pinene. phenolic p-coumaric acid, ellagic acid caffeic acid. showed good antioxidant radical scavenging reducing potential a very protect oxidation. moderate AChE BChE inhibition potential, weak or no ability.